Gago, Gabriela

Gabriela Gago has a degree in Biotechnology from the Faculty of Biochemical and Pharmaceutical Sciences (FCByF) of the UNR, she completed her PhD in the Molecular Biology Area of the same Faculty under the supervision of Dr. Raquel Chan and Dr. Daniel Gonzalez. He carried out postdoctoral research at the IBR under the supervision of Hugo Gramajo and at the Global Health Institute in Lausanne (Switzerland) under the supervision of Stewart Cole. She is currently an Independent Researcher at CONICET and Associate Professor of Molecular Biology at FCByF. She works in the Physiology and Genetics of Actinomycetes group, where she leads studies related to the characterization of enzymes involved in lipid synthesis and their regulation in Mycobacterium tuberculosis, particularly those involved in the synthesis of phospholipids and triacylglycerides and in the communication of the two fatty acid synthase systems present in this pathogen.

Twitter: @GabrielaGago4  IG: @gabriela_gago

Orcid

Scopus 


Directed Project:

Characterization of essential proteins for the coordination of Mycobacterium tuberculosis cell envelope synthesis during Infection

The aim of this research line is to provide information about the mechanisms that allow M. tuberculosis to adapt the expression of its cell envelope components in response to the environmental changes encountered in the host during infection. We aim to characterize the physiological role of FabH during infection, a key enzyme in the synthesis of mycolic acids. The synthesis pathways of phospholipids and TAGs are coordinated and share common enzymes and substrates, being phosphatidic acid (PA) a key intermediate. Enzymes involved in PA synthesis have not yet been characterized in mycobacteria, and therefore, we propose to elucidate these essential enzymatic steps for membrane biosynthesis. The analysis of the results will provide tools to understand how lipid synthesis is coordinated in M. tuberculosis and its role during infection, potentially offering new targets for the design of new antimycobacterial compounds.

Directed Human Resources:

PhD Students

Publicaciones:

  • Crotta Asis A, et al Characterization of key enzymes involved in triacylglycerol biosynthesis in mycobacteria. 2021 Scientific Reports | Ver Publicación

  • Mondino S, et al FasR Regulates Fatty Acid Biosynthesis and Is Essential for Virulence of Mycobacterium tuberculosis. 2020 Frontiers in Microbiology | Ver Publicación

  • Gago G, Diacovich L, Gramajo H. Lipid metabolism and its implication in mycobacteria-host interaction.. 2017 "Curr Opin Microbiol. 2017 Nov 27;41:36-42. doi: 10.1016/j.mib.2017.11.020. [Epub ahead of print] Review. PMID: 29190491" | Ver Publicación

  • Lara, J, et al Mycobacterium tuberculosis FasR senses long fatty acyl-CoA through a tunnel and a hydrophobic transmission spine. 2020 Nature Communications | Ver Publicación